Carles Vilarino-Guell
University of British Columbia
Term: 3/1/2018 – 2/28/2019
Project Overview
Through the study of families with several family members diagnosed with MS, this team has recently identified a mutation in a gene called NR1H3 (also known as LXRA) which is associated with progressive MS. They have now created a mouse model with this mutation to be able to study the biological mechanisms responsible for the onset of MS. Now they are studying this model further, to explore the biological processes altered by this mutation, and observe any deficiencies in mobility and memory. The knowledge gained in this study may help to effectively stop the progression of MS.
Project Overview
Through the study of families with several family members diagnosed with MS, this team has recently identified a mutation in a gene called NR1H3 (also known as LXRA) which is associated with progressive MS. They have now created a mouse model with this mutation to be able to study the biological mechanisms responsible for the onset of MS. Now they are studying this model further, to explore the biological processes altered by this mutation, and observe any deficiencies in mobility and memory. The knowledge gained in this study may help to effectively stop the progression of MS.